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KMID : 0617219920030010025
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Duksung Bulletin Phamaceutical Sciences
1992 Volume.3 No. 1 p.25 ~ p.29
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Effects of Ieucovorin on the pharmacokinetics of methotrexate in rabbits
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Chang, Hong Won
Lee, Myung Gull/Lee, Hee joo/Park, Man Ki/Kim, Chong Kook
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Abstract
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The effects of leucovorin on the pharmacokinetics of methotrexate(MTX) were studied in rabbits. The renal tubular secretion of MTX appeared to be inhibited by administration of leucovorin, however, the efflux of MTX from the cell and/or re-entry of MTX into the cell did not seem to be affected by administrationof leucovorin.
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